bindningsdynamikk
Bindningsdynamik, or binding dynamics, is the study of how binding partners such as proteins, ligands, nucleic acids, or ions interact through association and dissociation over time. It concerns the rates, mechanisms, and pathways of binding events and how structural features and the surrounding environment shape these processes. The kinetics of binding are described by rate constants and by models that relate these rates to observed affinity and occupancy.
Key concepts include the association rate constant k_on and the dissociation rate constant k_off, whose ratio
Experimental approaches to study binding dynamics include isothermal titration calorimetry (ITC) for thermodynamics and affinity, surface
Applications span biochemistry, pharmacology, and molecular biology. Binding dynamics determine signal transduction, enzyme regulation, and drug