autoimmuunigastritis
Autoimmune gastritis, also known as autoimmune metaplastic atrophic gastritis (AMAG), is a chronic immune-mediated inflammatory disease of the stomach lining. It primarily affects the gastric body and fundus, leading to loss of parietal cells, reduced acid production (hypochlorhydria or achlorhydria), and impaired intrinsic factor production.
The condition is driven by autoantibodies against gastric parietal cells and intrinsic factor, with T-cell–mediated injury
Most cases are asymptomatic or present with nonspecific dyspepsia. Pernicious anemia may develop due to vitamin
Diagnosis relies on a combination of serology and histology. Serologic tests may detect anti-parietal cell antibodies
Complications include pernicious anemia and an elevated risk of gastric neoplasia, including intestinal-type gastric cancer and