angiogenics

Angiogenics is a term used to describe substances or processes that promote angiogenesis. Angiogenesis is the physiological process through which new blood vessels form from pre-existing ones. This is a normal and vital process in growth and development, as well as in wound healing. However, it is also a crucial step in tumor growth and metastasis, as tumors require a blood supply to grow beyond a certain size and to spread to other parts of the body.

Angiogenic factors are signaling proteins that stimulate the formation of new blood vessels. Vascular endothelial growth factor (VEGF) is a key example of an angiogenic factor. These factors are released by cells in response to various stimuli, including low oxygen levels. They then bind to receptors on the surface of endothelial cells, the cells that line blood vessels, triggering a cascade of events that leads to the growth of new capillaries.

The study of angiogenics has significant implications for medicine. Therapies that inhibit angiogenesis are being developed to treat cancer by starving tumors of their blood supply. Conversely, therapies that promote angiogenesis are being investigated for conditions where improved blood flow is beneficial, such as in the treatment of cardiovascular diseases and wound healing. Understanding the complex mechanisms of angiogenesis and the factors that regulate it is crucial for developing effective therapeutic strategies.