Zebrafischmodellen

The Zebrafish model, scientifically known as Danio rerio, has become an indispensable tool in biological and biomedical research. These small, freshwater fish, native to the Indian subcontinent, possess several characteristics that make them highly advantageous for scientific studies. Their rapid external fertilization and development, coupled with a relatively short generation time, allow researchers to observe multiple generations and study developmental processes quickly.

A key feature of the zebrafish model is its optical transparency in the larval stage. This allows for non-invasive, in vivo imaging of internal organs and cellular processes, offering insights into embryogenesis, organogenesis, and disease progression without the need for sacrificing the animal at early stages. Furthermore, zebrafish share a significant genetic homology with humans, with approximately 70% of human genes having a zebrafish counterpart. This genetic similarity makes them a valuable model for studying human diseases, including cancer, cardiovascular disorders, neurological conditions, and infectious diseases.

The development of powerful genetic tools, such as transgenesis and gene editing technologies like CRISPR-Cas9, has further enhanced the utility of zebrafish. Researchers can easily generate genetically modified zebrafish to mimic human genetic mutations and diseases, create disease models, and study gene function. Their relatively low cost of maintenance and high fecundity also contribute to their widespread adoption in laboratories globally. Zebrafish research has led to significant advancements in understanding fundamental biological processes and has contributed to the development of new therapeutic strategies.