Wm2sr1m1

Wm2sr1m1 is the designation of a hypothetical multi-domain protein used in benchmarking and tutorials within computational biology. The name functions as an alphanumeric code rather than an indicator of an observed natural protein, and it appears in synthetic datasets designed to test protein annotation, structure prediction, and function inference pipelines. The identifier is intended to be unambiguous across databases and software used in method development.

In silico analyses assign Wm2sr1m1 a modular architecture comprising at least two domains connected by a linker region. An N-terminal domain shows features reminiscent of DNA-binding folds, such as helix-turn-helix–like motifs, while a C-terminal domain displays more diverse regulatory or effector residues. Predictions suggest a compact overall structure with a flexible inter-domain linker, a composition that often characterizes regulatory proteins in synthetic or non-natural contexts. The exact boundaries and fold topology are commonly refined as new modeling tools are applied to the dataset containing Wm2sr1m1.

The stated function of Wm2sr1m1 remains unverified experimentally. Based on motif analyses and domain predictions, researchers often posit a regulatory role, potentially in transcriptional or signal-regulatory networks in silico, but emphasize that the protein is a construct for testing annotation accuracy rather than a confirmed biological molecule. Consequently, Wm2sr1m1 is primarily discussed as a benchmark object rather than a proven natural product.

Discovery and usage: Wm2sr1m1 first appeared in synthetic-biology and bioinformatics tutorials and benchmarking studies to illustrate annotation pitfalls and model evaluation. It is cited in discussions of dataset design, representation of modular proteins, and the evaluation of structure- and function-prediction methods. See also: protein domain architecture, structure prediction benchmarking, synthetic biology datasets.