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VIPsecreting

VIPsecreting refers to the biology of producing and releasing vasoactive intestinal peptide (VIP), a neuropeptide that serves as a neurotransmitter, neuroendocrine signal, and immunomodulator. VIPsecreting cells include enteric neurons and other components of the autonomic nervous system, as well as certain neuroendocrine cell populations. VIP is synthesized as a precursor and processed to its mature form, stored in secretory vesicles, and released in response to neuronal activity, calcium signaling, or inflammatory cues.

VIP exerts its effects by binding to G protein–coupled receptors VPAC1 and VPAC2, leading to increased intracellular

Physiologically, VIPsecreting systems contribute to gastrointestinal motility and secretion, airway tone, mucosal immunity, and certain aspects

Research methods for VIPsecreting activity include immunoassays and radioimmunoassays for VIP in plasma or tissue, immunohistochemistry

cAMP.
Through
these
receptors,
VIP
promotes
relaxation
of
smooth
muscle,
vasodilation,
and
stimulation
of
secretions
in
the
gut
and
pancreas,
as
well
as
bronchodilation.
It
also
modulates
immune
cell
activity,
generally
supporting
anti-inflammatory
and
regulatory
pathways
in
diverse
tissues.
of
neuroendocrine
regulation.
Dysregulation
of
VIP
signaling
has
been
linked
to
inflammatory
and
inflammatory-like
conditions
in
the
gut
and
airways,
among
other
disorders.
The
therapeutic
potential
of
VIP
or
VPAC
agonists
has
been
investigated
in
preclinical
and
early
clinical
settings
for
inflammatory
and
immune-mediated
diseases.
to
identify
VIP-containing
cells,
and
functional
assays
of
VPAC
receptor
signaling
to
assess
responsiveness
and
secretion
dynamics.