TRPV34

There is no widely recognized human protein named TRPV34. The transient receptor potential vanilloid (TRPV) subfamily comprises TRPV1 through TRPV6, with TRPV4 being the closest and most studied member. If you intended TRPV4, the following summarizes its characteristics.

Transient receptor potential vanilloid 4 (TRPV4) is a nonselective cation channel that forms functional homotetramers. Each subunit contains six transmembrane segments with a pore loop between S5 and S6, and it has cytoplasmic N- and C-termini. TRPV4 gates in response to diverse stimuli, including osmotic cell swelling, mechanical stimuli such as shear stress or membrane tension, and warm temperatures within the physiological range. Pharmacological activators include GSK1016790A and 4α-phorbol-didecanoate, while several antagonists, such as HC-067047, have been described to inhibit its activity. Regulation is further influenced by phospholipids like PIP2 and by interactions with cytoskeletal and signaling proteins.

TRPV4 is widely expressed in multiple tissues, notably the kidney, vascular endothelium, cartilage, skin, and various brain regions. Its physiological roles encompass osmoregulation, mechanosensation, thermosensation, vascular permeability, and participation in inflammatory signaling. In the musculoskeletal system, TRPV4 activity influences chondrocyte and osteoblast function and skeletal development.

Clinical relevance includes skeletal dysplasias caused by dominant gain-of-function mutations in TRPV4, such as metatropic dysplasia and brachyolmia. Altered TRPV4 activity has also been linked to neuropathic pain and edema, making it a target of interest for therapeutic intervention. If you specifically seek information on a channel named TRPV34, no canonical entry is currently recognized; details here pertain to TRPV4, the nearest characterized member.