T2SSbearing
T2SSbearing is a proposed component associated with the Type II Secretion System (T2SS) of many Gram-negative bacteria. The T2SS mediates the translocation of folded proteins from the periplasm across the outer membrane, functioning through a complex assembly that includes an inner membrane platform, a pseudopilus, and an ATPase. In some architectural models, bearing-like elements are hypothesized to provide mechanical support and rotational stabilization for the secretion motor.
Functionally, if present, a T2SSbearing would be expected to help align moving parts such as the ATPase,
Localization and composition remain areas of active investigation. In silico and biochemical data have suggested that
Genetic distribution is uneven across species. T2SSbearing-related features have been noted in a subset of proteobacterial
Current status remains tentative. T2SSbearing is considered a hypothetical or model-based concept rather than a universally