Sesamin

Sesamin is a major lignan found in sesame seeds (Sesamum indicum) and in sesame oil. It is a lignan, a type of plant polyphenol formed from phenylpropanoid units, and is one of the most abundant lignans in sesame products alongside related compounds such as sesamolin and sesaminol.

Sesamin occurs naturally in sesame products, and its content varies with sesame variety and processing. It is commonly present at high levels in seeds and oil, though roasting and extraction methods can alter its concentration.

Biological activity and research: In vitro and animal studies have reported antioxidant and anti-inflammatory effects for sesamin, and some evidence suggests it may influence lipid metabolism and blood pressure. Human data are limited and results are inconsistent, with no conclusive conclusions about clinically meaningful benefits.

Metabolism and safety: When consumed, sesamin is metabolized by gut microbiota to mammalian lignans such as enterodiol and enterolactone, which may contribute to observed effects. Some studies indicate sesamin can interact with drug-metabolizing enzymes in experimental settings, but the clinical relevance is uncertain. Sesame seeds are a common food, but sesame allergy is a known risk and can be severe in sensitive individuals. High-dose sesamin supplements are not widely approved as medicines and should be used with caution, preferably under medical supervision.