Highdose

Highdose is a term used to describe a dose of a substance that exceeds the typical therapeutic range or recommended dose. In medical literature, “high-dose” denotes regimens designed to achieve greater biological effect, often with increased risk of toxicity. The designation is relative to the drug, patient, and indication; what counts as high dose for one drug or individual may be standard for another.

In clinical contexts, high-dose regimens are employed in several fields, notably oncology (high-dose chemotherapy regimens sometimes followed by autologous stem cell rescue), infectious disease (high-dose antibiotic or antifungal therapy for severe infections or resistant organisms), and other areas where intensified therapy is considered. Dosing is typically guided by clinical protocols, research data, and pharmacokinetic/toxicology considerations, and requires specialized monitoring due to risks such as organ toxicity, cytopenias, or electrolyte disturbances.

Safety and regulation: High-dose therapies require medical supervision in appropriate settings. Patient factors such as age, renal or hepatic function, and comorbidities influence dosing decisions, and deviations can lead to serious adverse effects.

Branding and media usage: The term has also been used as a brand name or title by various companies or media projects. Such uses vary by jurisdiction and product and are not standardized, and are separate from the medical concept of high-dose regimens.

See also: dosage, overdose, high-dose therapy, chemotherapy, antimicrobial therapy, pharmacokinetics.