Semisynthesized
Semisynthesis, or semisynthesized, refers to the production of a compound by starting from a naturally derived molecule and making further chemical modifications to obtain a new substance that would be difficult to obtain by total synthesis alone. The term is often used interchangeably with semi-synthesis. Semisynthesized products occupy a middle ground between total synthesis and biosynthesis, leveraging the complexity of natural scaffolds while enabling tailored properties through targeted transformations.
In practice, semisynthesis is common in pharmaceuticals, particularly antibiotics and other biologically active natural products. Classic
The typical workflow involves obtaining a natural product or an intermediate through fermentation, extraction, or enzymatic
Advantages of semisynthesis include access to complex architectures that are difficult to build from scratch, potential