SH3domain
The SH3 domain, or Src Homology 3 domain, is a small protein interaction module found in a wide range of eukaryotic proteins, including Src family kinases and numerous adaptor and scaffold proteins. It mediates specific, low-to-moderate affinity interactions with proline-rich ligands, enabling the assembly of signaling complexes and coordination of cellular processes such as cytoskeletal organization and endocytosis.
Structurally, the SH3 domain is a compact beta-barrel composed of about 60 amino acids arranged into five
Binding and specificity are centered on proline-rich sequences, commonly containing PxxP motifs. SH3 domains typically recognize
Biological roles of SH3 domains include recruiting kinases, phosphatases, and structural proteins to signaling complexes, shaping