Resorptionrelated

Resorption-related refers to processes, factors, or conditions that involve resorption, the biological breakdown and removal of mineralized tissue or cellular components. In biology, resorption is a normal part of tissue turnover and remodeling, as well as a response to injury or disease. The most studied example is bone resorption, driven by osteoclasts that dissolve mineralized matrix and release minerals into circulation. Resorption also occurs in teeth, where odontoclasts can remove dental hard tissue during development, eruption, or under pathological stimuli.

Mechanisms underlying resorption involve coordinated cellular activity and signaling. Osteoclasts resorb by creating an acidic microenvironment and secreting proteolytic enzymes such as cathepsin K, while osteoblasts drive subsequent formation to restore the tissue balance. The activity is regulated by the RANK-RANKL-OPG signaling axis, along with mechanical forces, hormonal signals, and local inflammatory mediators. Imbalance can shift toward excessive resorption, contributing to conditions such as osteoporosis or pathologic tooth resorption.

Resorption can be physiological or pathological. Physiological resorption includes normal bone remodeling and dental processes like shedding of deciduous teeth or tooth eruption. Pathological resorption results from inflammation, infection, pressure from lesions or orthodontic forces, trauma, or neoplastic processes, potentially compromising structural integrity and function.

In clinical practice, resorption-related changes are assessed via imaging methods such as radiographs and cone-beam computed tomography, with histology used in research settings. Management focuses on addressing the underlying cause, minimizing triggering forces, and, when necessary, endodontic or surgical interventions. In research and medicine, the term resorption-related is used to describe pathways, genes, or stimuli that contribute to resorptive processes.