ProteomEbene
ProteomEbene, often rendered in German as Proteom-Ebene, is a conceptual layer in systems biology that refers to the complete set of proteins expressed by a cell, tissue, or organism under specific conditions. It includes not only protein abundance but also proteoforms arising from alternative splicing, post-translational modifications, and proteolytic processing, as well as subcellular localization and interaction networks. The ProteomEbene serves as a functional intermediary between the genome and the phenotypic state, translating genetic information into cellular activity.
Measurement and analysis of the ProteomEbene rely on proteomics technologies, primarily mass spectrometry. Workflows typically involve
Applications and challenges: The ProteomEbene is central to biomarker discovery, understanding disease mechanisms, and informing drug
Outlook: Advances in quantitative, spatial, and single-cell proteomics, along with improved data standards and multi-omics integration,