PromoterEnhancerKontakte
PromoterEnhancerKontakte refers to the three‑dimensional interactions between DNA regulatory elements—specifically promoters and enhancers—that enable precise control of gene expression in eukaryotic cells. Promoters are DNA sequences located near the transcription start site of a gene and serve as binding platforms for the basal transcriptional machinery, while enhancers are distal sequences that can modulate the transcriptional output of a promoter over large genomic distances. When a promoter and an enhancer physically contact one another within the nucleus, they can recruit co‑activators and other factors that facilitate the assembly of the transcription pre‑initiation complex, thereby elevating or repressing transcription.
These contacts are mediated by protein complexes that form chromatin loops. Architectural proteins such as CTCF
Several experimental approaches map PromoterEnhancerKontakte. Hi‑C and its variants (Capture‑Hi‑C, PLAC‑seq) provide genome‑wide interaction maps, while
Aberrant promoter‑enhancer contacts are implicated in disease. Mis‑localization of enhancers or erroneous loop formation can lead