Phosgenebased
Phosgene-based is an adjective describing processes, materials, or reagents that rely on phosgene (COCl2) as a carbonylating agent or building block. Phosgene is a highly toxic, colorless gas with a suffocating odor and has a long history in chemical synthesis as well as in chemical warfare; its handling is tightly regulated worldwide.
In industrial chemistry, phosgene-based routes are used to manufacture polycarbonates by reacting bisphenol A with phosgene
Because of toxicity and occupational hazards, many companies pursue phosgene-free routes or substitutes such as solid
Safety considerations are central to phosgene-based work and include strict controls, closed-system handling, air monitoring, scrubbing
See also: phosgene, polycarbonate, isocyanate, phosgenation, and phosgene-free polycarbonate.