PTBdomeenien
PTBdomeenien are a family of protein domains known as phosphotyrosine-binding (PTB) domains. They are found in a variety of signaling and cargo-adaptor proteins and function primarily to mediate protein–protein interactions by recognizing specific peptide motifs, often containing phosphorylated tyrosine residues.
Structure and binding characteristics
PTBdomeenien are typically small modules, about 100 to 120 amino acids in length, and adopt a beta-sandwich
PTBdomeenien play key roles in signal transduction and intracellular trafficking. They often recruit effector proteins to
PTBdomeenien occur across a wide range of eukaryotes and are embedded in various multi-domain proteins, including
Research and clinical relevance
Structural and biochemical studies have elucidated many PTBdomeenien structures and binding motifs, informing models of their
SH2 domains, PDZ domains, PH domains, endocytosis, receptor signaling.