PINtransporters
PINtransporters are a proposed family of membrane transport proteins implicated in the translocation of polar and charged molecules across biological membranes. The term is used in a growing body of literature to describe proteins that share a conserved sequence motif, referred to as the PIN motif, and a predicted multi-pass transmembrane architecture. Because the group is still under active study, functional properties and substrate ranges are described as variable across subfamilies.
Structure and mechanism are central to the concept of PINtransporters. Bioinformatic analyses predict six to twelve
Distribution and genetics are also topics of interest. PINtransporters have been identified in diverse taxa, including
Regulation and evolution are active areas of research. Expression patterns reportedly respond to nutrient status and
Research and applications focus on understanding the basic biology of PINtransporters and exploring potential uses in