PI3KmTOR
PI3KmTOR is a signaling pathway that plays a crucial role in various cellular processes, including cell growth, proliferation, survival, and metabolism. The pathway is composed of two main components: the phosphoinositide 3-kinase (PI3K) and the mechanistic target of rapamycin (mTOR). PI3K is a family of lipid kinases that catalyze the phosphorylation of phosphatidylinositol (PI) at the 3-position, generating phosphatidylinositol-3,4,5-trisphosphate (PIP3). PIP3 serves as a second messenger, recruiting and activating various downstream effectors, including the serine/threonine kinase mTOR.
mTOR is a serine/threonine protein kinase that exists in two distinct complexes: mTORC1 and mTORC2. mTORC1 is
The PI3KmTOR pathway is frequently dysregulated in various diseases, including cancer, diabetes, and neurodegenerative disorders. Activation
Targeting the PI3KmTOR pathway has emerged as a promising therapeutic strategy for various diseases. Inhibitors of