Nup107160

Nup107160, also known as Nup107 or NUP107-160 complex, is a crucial component of the nuclear pore complex (NPC) in eukaryotic cells. The NPC is a large molecular machine embedded in the nuclear envelope that regulates the transport of molecules between the nucleus and the cytoplasm. The Nup107160 complex itself is a significant subcomplex within the NPC, consisting of multiple nucleoporins, including Nup107, Nup160, Nup145, Nup96, Nup85, Nup62, Nup58, and Nup54.

This complex plays a vital role in the structural organization and assembly of the NPC. It is primarily located in the inner ring and spoke regions of the NPC, contributing to its overall scaffold and stability. Furthermore, the Nup107160 complex is implicated in the mediation of nuclear transport, though its precise function in this process is still under investigation. It is thought to interact with transport receptors and other NPC components to facilitate the passage of molecules.

Disruptions in the function or assembly of the Nup107160 complex have been linked to various cellular defects and diseases. For example, mutations or misexpression of its constituent nucleoporins have been observed in certain cancers and developmental disorders, highlighting its importance in maintaining nuclear integrity and cellular function. Research into the Nup107160 complex continues to unravel its intricate roles in nuclear transport and genome stability.