Nup85

Nup85, also known as Nuclear Pore Complex Protein 85, is a component of the nuclear pore complex (NPC). The NPC is a large protein structure that spans the nuclear envelope in eukaryotic cells, regulating the transport of molecules between the nucleus and the cytoplasm. Nup85 is a transmembrane protein and plays a crucial role in the structural integrity and assembly of the NPC.

It belongs to the larger family of nucleoporins, which are the proteins that make up the NPC. Nup85 is conserved across many species, indicating its fundamental importance in cellular function. Research suggests that Nup85 interacts with other nucleoporins to form subcomplexes within the NPC, contributing to its overall architecture and gating mechanism. The proper functioning of Nup85 is essential for maintaining nuclear transport homeostasis, which is vital for gene expression, protein synthesis, and other cellular processes. Disruptions in Nup85 function have been implicated in various cellular abnormalities and diseases.