Nup107

Nup107 refers to a component of the nuclear pore complex (NPC), a large protein structure embedded in the nuclear envelope that regulates the transport of molecules between the nucleus and the cytoplasm. Specifically, Nup107 is part of the Nup107-160 complex, which is a crucial structural element of the NPC. This complex is found at the nuclear face of the NPC and plays a vital role in NPC assembly and maintenance. It is also implicated in nuclear envelope reformation after mitosis. The Nup107-160 complex is composed of several nucleoporins, including Nup107, Nup160, Nup133, Nup96, and Nup85. Mutations or dysregulation of Nup107 have been linked to various cellular processes and developmental defects, highlighting its importance in nuclear transport and nuclear architecture. The Nup107-160 complex is believed to form a scaffold that anchors other NPC components and facilitates the selective passage of macromolecules.