Nup96

Nup96 is a protein that plays a crucial role in the regulation of gene expression and DNA repair. It is a component of the nucleosome, the fundamental unit of DNA packaging in eukaryotic cells. Nup96 is part of the nucleoporin family, which are proteins that form the nuclear pore complex, a large protein complex that regulates the transport of molecules between the nucleus and the cytoplasm.

Nup96 is involved in various cellular processes, including DNA replication, transcription, and repair. It interacts with other nucleoporins and with proteins involved in DNA metabolism, such as replication protein A (RPA) and the DNA repair protein Rad51. Nup96 is also involved in the regulation of chromatin structure and gene expression, as it can influence the accessibility of DNA to transcription factors and other regulatory proteins.

Nup96 is essential for cell viability, and its depletion or dysfunction can lead to various diseases, including cancer and neurodegenerative disorders. For example, mutations in Nup96 have been linked to a rare form of cancer called malignant rhabdoid tumor, as well as to neurodegenerative diseases such as Alzheimer's and Parkinson's. Additionally, Nup96 has been implicated in the development of autoimmune diseases, such as systemic lupus erythematosus and rheumatoid arthritis.

The study of Nup96 and its role in cellular processes continues to be an active area of research, with the goal of understanding its function in health and disease and developing potential therapeutic strategies for related disorders.