Nitratpflaster

Nitratpflaster, also known as nitroglycerin patches or transdermal nitroglycerin, are a type of medication delivery system used primarily for the treatment and prevention of angina pectoris, a chest pain caused by reduced blood flow to the heart. These patches contain nitroglycerin, a vasodilator, which is released slowly and consistently through the skin into the bloodstream.

The mechanism of action involves the dilation of blood vessels, particularly the coronary arteries that supply the heart muscle. This widening of the arteries increases blood flow and oxygen supply to the heart, thereby relieving the strain and preventing the onset of chest pain. The transdermal delivery allows for a sustained release of the medication, providing continuous therapeutic levels over a period of 24 hours.

Nitratpflaster are typically applied to intact skin, commonly on the chest, upper arm, or thigh. The application site should be rotated regularly to prevent skin irritation. It is important to follow the prescribing physician's instructions regarding the size of the patch, the duration of wear, and the timing of application and removal. Some treatment regimens involve a nitrate-free interval each day to prevent the development of tolerance to the medication.

Common side effects can include headache, dizziness, flushing, and a drop in blood pressure. These are often temporary and may subside as the body adjusts to the medication. In rare cases, more serious side effects can occur. Nitratpflaster are contraindicated in individuals with certain heart conditions, such as severe anemia or a history of hypersensitivity to nitrates. They should also be used with caution in combination with other medications that can lower blood pressure.