Neuromedins
Neuromedins are a family of endogenous signaling peptides expressed in the nervous system of vertebrates. They are produced from larger precursor proteins and processed by proteolytic enzymes into multiple active peptides that are released at synapses and, in some cases, from non-synaptic sites. Most neuromedins are short, typically eight to twenty amino acids, and often undergo C-terminal amidation or other post-translational modifications that increase stability and receptor affinity.
Neuromedins exert their effects by binding to a set of neuromedin receptors, a small family of G
Functions attributed to neuromedins include modulation of synaptic transmission and plasticity, regulation of feeding and energy
Research on neuromedins is ongoing, with interest in their potential as therapeutic targets for chronic pain,