NegB
NegB is a term used in synthetic biology and computational modeling to denote a hypothetical negative regulator within a gene regulatory circuit, often described as a “negative regulator of pathway B.” It does not denote a verified natural protein; rather, NegB serves as an illustrative construct to study how negative feedback can shape gene expression dynamics.
In commonly used models, NegB encodes a DNA-binding repressor that is produced in response to signals or
Applications include teaching and the testing of control theory concepts in biology, as well as guiding the
Limitations and considerations include promoter strength, protein degradation rates, and signal latency; mismatches between model assumptions