Mlphmediated
Mlphmediated refers to cellular processes controlled by melanophilin (MLPH), a Rab27a effector protein that functions as an adaptor linking melanosomes to the motor protein myosin Va. In vertebrate pigment cells, this adaptor-mediated mechanism is essential for the proper distribution of pigment-containing organelles to dendritic extensions and peripheral regions of the cell, contributing to even pigmentation.
Mechanistically, Rab27a localizes to melanosome membranes and binds to MLPH, which in turn recruits myosin Va.
Biological significance of Mlphmediated transport includes its critical role in normal coat color and pigmentation patterns
Clinical relevance is highlighted by mutations in the MLPH gene, which cause Griscelli syndrome type 3, a
Other notes: The Mlphmediated pathway interacts with the broader Rab27a effector network and can influence secretory