MYCN
MYCN is a gene that encodes the N-Myc transcription factor, a member of the MYC family. The human MYCN gene is located on chromosome 2p24–25. The N-Myc protein contains a basic helix-loop-helix leucine zipper (bHLH-LZ) domain that enables DNA binding and dimerization with MAX.
As a transcription factor, N-Myc forms heterodimers with MAX and binds to E-box DNA sequences in target
Expression of N-Myc is tightly regulated at transcriptional and post-translational levels. The ubiquitin–proteasome system governs its
The best characterized clinical role of MYCN is in neuroblastoma, where gene amplification occurs in a substantial
Alterations of MYCN have also been reported in other cancers and can be associated with aggressive tumor