MSMS

MSMS is an acronym used in multiple scientific and technical domains. In analytical chemistry and biochemistry, MSMS commonly refers to tandem mass spectrometry (MS/MS), a technique in which selected precursor ions are isolated and fragmented to produce product ions. This approach enables identification and structural characterization of molecules in complex mixtures, with applications in proteomics, metabolomics, and pharmaceutical analytics. Modern MS/MS workflows integrate high-resolution instrumentation, fragmentation methods such as collision-induced dissociation or higher-energy collisional dissociation, and sophisticated data analysis to match observed spectra with spectral libraries or predict fragment patterns. Quantitative and qualitative analyses rely on robust calibration, standardization, and careful control of parameters to ensure reproducibility.

In computational chemistry and structural biology, MSMS is the name of a software package used to generate molecular surfaces and compute properties like solvent-accessible surface area and buried surface area. The program creates triangulated surface meshes for macromolecules and small molecules, serving as a preprocessing step for visualization, docking, electrostatics, and surface-based analyses. It is widely cited in the literature and has informed many later tools and workflows, often operating as a standalone program or integrated into larger modeling suites.

The exact meaning of MSMS can vary by field, and in any given context it is best to consult the source material to confirm which MSMS is being referenced.