MS3

MS3 is a designation used across several domains to denote a third version, stage, or model in a sequence that is sometimes labeled MS1, MS2, MS3. Because the term is not tied to a single, universal entity, its meaning depends on the specific field or organization employing it.

In science and technology, MS3 most commonly refers to three-stage mass spectrometry. In this workflow, an ion is first analyzed (MS1), then selected and fragmented to produce MS2 spectra. A chosen fragment ion from MS2 is subsequently fragmented again to yield MS3 spectra. This approach can provide additional specificity and structural information, and it is particularly used in quantitative proteomics to improve accuracy when using isobaric labeling techniques such as TMT or iTRAQ, by reducing interference from co-isolated ions.

Other uses of MS3 are more varied and context-dependent. In some industries, MS3 may appear as a model number, product revision, or project designation within an organization. Because there is no single standardized meaning, identifying the precise definition requires accompanying context such as a product sheet, research protocol, or documentation from the relevant field.

Summary: MS3 most often denotes a three-stage or third-version concept in technical settings, with the specific interpretation determined by discipline and context. When encountering MS3, it is helpful to refer to the immediate surrounding materials to confirm its exact meaning.