MEN1tekijä

MEN1tekijä is a Finnish term that translates to "MEN1 gene" or "MEN1 factor" in English. It refers to the gene responsible for Multiple Endocrine Neoplasia type 1 (MEN1). This gene is a tumor suppressor gene, meaning it normally helps to prevent the formation of tumors. When this gene is mutated or inactivated, it can lead to the development of tumors in various endocrine glands.

The MEN1 gene is located on chromosome 11. It encodes a protein called menin, which plays a role in regulating cell growth and differentiation. Mutations in the MEN1 gene are inherited in an autosomal dominant pattern, meaning that a person only needs to inherit one mutated copy of the gene from a parent to be at increased risk of developing MEN1. However, sporadic mutations can also occur.

The tumors associated with MEN1 typically develop in the parathyroid glands, pituitary gland, and pancreas. Parathyroid tumors are the most common, often leading to hyperparathyroidism. Pancreatic tumors can include gastrinomas, insulinomas, and other neuroendocrine tumors. Pituitary tumors can cause various hormonal imbalances.

Diagnosis of MEN1 is usually based on clinical symptoms, biochemical tests, and genetic testing for mutations in the MEN1 gene. Management involves regular screening for tumors and surgical intervention when necessary to remove tumors and manage hormonal imbalances. The prognosis for individuals with MEN1 varies depending on the type and extent of tumors present.