MECL1PSMB10

MECL1PSMB10 is not a widely recognized, independent gene symbol in major human genome databases. In practice, it commonly denotes the proteasome subunit beta type-10, also known as MECL-1, which is encoded by the PSMB10 gene. The concatenated form may arise from dataset annotations that merge an alias (MECL-1) with the official gene symbol (PSMB10).

PSMB10 encodes a catalytic subunit of the immunoproteasome, a specialized form of the proteasome that is induced in response to inflammatory signals such as interferon-gamma. In immune cells, MECL-1/PSMB10 replaces the corresponding subunit of the constitutive proteasome and participates in proteolysis to generate peptide fragments that are preferentially presented by MHC class I molecules. The immunoproteasome exhibits distinct catalytic activities that influence antigen quality and quantity for immune surveillance.

Biological significance includes its role in shaping T cell responses through antigen processing and presentation. Expression of PSMB10 is typically higher in immune tissues and upregulated under inflammatory conditions. The immunoproteasome also contributes to general protein quality control and may participate in responses to viral infection and autoimmune processes.

Clinical and research relevance is active in areas exploring immune regulation, infection, autoimmunity, and cancer. Immunoproteasome subunits, including PSMB10, are studied as potential therapeutic targets, with inhibitors under investigation to modulate immune function. However, exact roles can vary by tissue context and disease state, and the use of the MECL1PSMB10 label is generally a note to verify the official symbol.

Note: when encountering the symbol MECL1PSMB10, researchers should verify whether it refers to PSMB10/MECL-1 and consult current nomenclature databases such as HGNC, UniProt, and NCBI Gene to confirm official symbols and aliases.