MAPKaltered
MAPKaltered refers to modifications or dysregulations within the Mitogen-Activated Protein Kinase (MAPK) signaling pathway. This pathway is a crucial cellular cascade involved in a wide array of cellular processes, including cell proliferation, differentiation, survival, and apoptosis. It plays a vital role in responding to external stimuli such as growth factors, cytokines, and stress signals.
The MAPK pathway is a complex network of interconnected proteins, typically involving three or four tiers of
MAPKaltered states can arise from various genetic mutations, epigenetic changes, or environmental factors that disrupt the
For instance, mutations in genes encoding components of the MAPK pathway, such as BRAF, KRAS, and EGFR,