Lysosomerelated
Lysosomerelated describes anything connected with lysosomes, the acidic organelles that degrade and recycle macromolecules in cells, and with lysosome-derived organelles that carry out specialized functions in different tissues. A common context is lysosome-related organelles (LROs), such as melanosomes in pigment cells, lytic granules in cytotoxic lymphocytes, and platelet dense bodies. These organelles share the endolysosomal origin but carry distinct cargo and surface proteins that reflect tissue-specific roles.
Lysosomerelated biology involves the biogenesis and trafficking routes that deliver enzymes and membranes to lysosomes and
Genetic disorders affecting lysosome-related pathways are categorized as LRO disorders. Hermansky-Pudlak syndrome (HPS) includes subtypes caused
Diagnosis relies on clinical assessment, genetic testing, and sometimes microscopy of cells to study organelle morphology.
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