Loxycodone

Loxycodone is not a widely recognized pharmaceutical name and is likely a misspelling or informal reference to oxycodone, a semi-synthetic opioid analgesic used for moderate to severe pain. Oxycodone acts as an agonist at mu-opioid receptors, producing analgesia by altering pain perception in the central nervous system. It is available in immediate-release forms for short-term pain and in extended-release formulations for ongoing management, and is often combined with acetaminophen (eg, oxycodone/acetaminophen) or with aspirin (oxycodone/aspirin).

Pharmacology and administration: Oxycodone is administered orally in various dosages and is absorbed readily with variable bioavailability. It is primarily metabolized in the liver by cytochrome P450 enzymes, especially CYP3A4 and CYP2D6, into several metabolites, including oxymorphone, which contributes to analgesic effect. It is excreted mainly in urine. Dosing is individualized based on the severity of pain, prior opioid exposure, and risk factors for misuse.

Medical use and indications: Oxycodone is indicated for the treatment of moderate to severe acute or chronic pain when non-opioid or shorter-acting therapies are insufficient. Extended-release formulations are used for persistent pain, including some cancer and non-cancer pain conditions, with careful monitoring for efficacy and safety.

Safety and regulatory status: Like other opioids, oxycodone carries risks of dependence, tolerance, misuse, respiratory depression, and overdose, particularly with higher doses or concurrent CNS depressants. Contraindications include significant respiratory impairment, acute or severe bronchial asthma, and paralytic ileus. In the United States, oxycodone products are controlled substances (Schedule II) and prescriptions are regulated to reduce misuse.