Lhx
Lhx, or LIM homeobox, refers to a family of transcription factors defined by the presence of two LIM zinc finger domains and a C-terminal homeobox DNA-binding domain. The LIM domains mediate protein–protein interactions, while the homeobox domain enables sequence-specific DNA binding. Many Lhx proteins act as transcriptional regulators in partnership with cofactors such as LIM-domain binding (LDB) proteins, enabling combinatorial control of gene expression.
In vertebrates, Lhx genes are grouped into several subfamilies, including Lhx1/2, Lhx3/4, Lhx5/6, and Lhx8, with
Functions: In the nervous system, Lhx genes influence neural progenitor identity, neuronal differentiation, and axon guidance.
Clinical relevance: Genetic alterations in Lhx genes can lead to developmental disorders in model organisms and,
Research and resources: Lhx genes are studied in mouse, zebrafish, and other model organisms. Typical approaches