Layersectoderm

Layersectoderm is a proposed layered dermal-tissue concept in speculative dermatology and tissue engineering describing a modular, lamellar arrangement of skin tissues across layers with distinct properties. It is meant to capture a segmented architecture that combines epidermal-like and dermal-like lamellae within a single construct.

The concept reflects a segmented, modular architecture in which epidermal-like lamellae alternating with dermal-like layers create defined interfaces and functional zones. This arrangement aims to emulate, or enhance, the functional division found in natural skin while enabling programmable features through controlled composition of each layer.

Structure includes alternating lamellae: an epidermal-like layer with stratified keratinocytes, a basement-membrane–like interface, and a dermal-like layer rich in collagen and elastin, sometimes incorporating microvascular networks and porous scaffolds. Some designs consider additional supporting strata to improve adhesion and integration with host tissue.

In practice, layersectoderm is pursued through bioprinting and self-assembly of cell-laden hydrogels, with interfaces stabilized by bioadhesives or crosslinkers. Mechanical testing reports higher tensile strength than comparable single-layer grafts, and models explore tunable permeability and barrier properties.

Potential benefits include improved barrier function, controlled diffusion of nutrients and drugs, and tunable pigmentation. Applications span wound healing, artificial skin grafts, cosmetic testing, and regenerative medicine. However, evidence remains largely preclinical, and the concept is not yet part of standard practice or widely adopted in clinical settings.

Current status remains experimental. Layersectoderm is not recognized as a standard anatomical term and lacks consensus nomenclature or widespread in vivo validation; further research, standardization, and ethical/regulatory review are needed.