Kudoskasvun

Kudoskasvun is a Finnish term that refers to tissue growth—the biological processes by which tissues increase in size or mass. It includes the enlargement of existing cells (hypertrophy), an increase in cell numbers (hyperplasia), and remodeling of the extracellular matrix that supports tissue structure. Kudoksen kasvu can occur during embryonic and postnatal development, after injury during healing and regeneration, or in response to sustained functional demands. It also covers changes in tissue composition that accompany these growth processes.

Kudoskasvun is driven by coordinated cellular and molecular mechanisms. Proliferation, differentiation, and survival of cells are governed by growth factors such as insulin-like growth factor (IGF), epidermal growth factor (EGF), and transforming growth factor beta (TGF-β), as well as hormones and cytokines. Angiogenesis supplies blood, oxygen, and nutrients needed for growth. Mechanical cues, nutrient status, and energy metabolism influence the rate and pattern of growth. Proper timing and localization are essential to ensure functional tissue architecture.

In development, kudoskasvun shapes organ size and function. In adults, it underlies tissue repair and regeneration after injury, muscle adaptation to training, and wound healing. Dysregulated kudoskasvun can contribute to fibrosis or scarring, and in some contexts to uncontrolled tissue proliferation such as tumors, highlighting the importance of regulatory balance.

Researchers study kudoskasvun through histology, imaging, and molecular assays. Proliferation markers like Ki-67, measurements of cell size, capillary density, and extracellular matrix content help quantify growth. Model systems include cell cultures, animal models, and human tissue studies.