Kollagenems

Kollagenems is a term used in some scientific discussions to denote enzymes involved in collagen metabolism. It is not a formal biochemical class but an umbrella label applied in limited contexts to capture the diverse enzymatic activities that build, modify, or break down collagen, the main structural protein of connective tissue. The exact scope of kollagenems can vary by source, but it generally encompasses enzymes that influence collagen biosynthesis, cross-linking, and degradation.

In the context of collagen synthesis and maturation, kollagenems may refer to enzymes such as prolyl and lysyl hydroxylases that modify procollagen chains during extracellular matrix formation, and lysyl oxidase, which catalyzes cross-link formation to stabilize collagen fibers. In degradation and remodeling, kollagenems can include matrix metalloproteinases (MMPs), particularly collagenases, as well as other proteases like cathepsins that cleave collagen-like substrates. These enzymes operate in concert with regulatory proteins, cofactors, and inhibitors to control tissue remodeling.

Regulation of kollagenems is tightly linked to physiological processes such as development, wound healing, aging, and fibrosis. Their activity is modulated by factors including tissue inhibitors of metalloproteinases (TIMPs), oxidative state, and nutrient availability (for example, vitamin C is essential for collagen hydroxylation). Dysregulation can contribute to diseases ranging from scar formation to cancer invasion.

See also: collagen, extracellular matrix, matrix metalloproteinases, collagen biosynthesis.