Kinaseides
Kinaseides are a class of small molecules that modulate the activity of protein kinases. Protein kinases are enzymes that play crucial roles in cellular signaling pathways by catalyzing the transfer of a phosphate group from ATP to specific amino acid residues on target proteins, a process known as phosphorylation. This phosphorylation event can activate or deactivate downstream signaling cascades, thereby regulating a wide array of cellular processes including cell growth, differentiation, metabolism, and apoptosis. Dysregulation of kinase activity is implicated in numerous diseases, most notably cancer, making kinases attractive targets for therapeutic intervention.
Kinaseides function by binding to kinases and altering their enzymatic activity. They can act as inhibitors,
The development of kinaseides has led to the creation of several successful drugs, particularly in oncology.