Integrinin
Integrins are a family of cell surface receptors that play a crucial role in cell adhesion. They are heterodimeric transmembrane proteins, meaning each integrin is composed of two distinct subunits: an alpha (α) subunit and a beta (β) subunit. There are at least 18 known α subunits and 8 known β subunits in mammals, which combine in various ways to form over 24 different integrin heterodimers. These heterodimers are expressed on the surface of most cells and are involved in a wide range of biological processes.
The primary function of integrins is to mediate cell-cell and cell-extracellular matrix (ECM) adhesion. They bind
Inside-out signaling involves intracellular events that alter integrin conformation and increase their affinity for extracellular ligands.