ITGB5

ITGB5, also known as integrin beta-5, is a protein that functions as a cell surface receptor. It is a member of the integrin family, which plays a crucial role in cell adhesion, migration, and signaling. Integrin beta-5 specifically pairs with integrin alpha-V to form the integrin alpha-V beta-5, which is involved in various biological processes.

Integrin alpha-V beta-5 is expressed on the surface of many cell types, including endothelial cells, smooth muscle cells, and fibroblasts. It is particularly notable for its role in the regulation of angiogenesis, the process by which new blood vessels form. This integrin is known to interact with several extracellular matrix proteins, such as fibronectin and vitronectin, facilitating cell adhesion and migration.

In addition to its role in angiogenesis, integrin alpha-V beta-5 is also involved in other cellular processes, including cell proliferation, differentiation, and apoptosis. Its expression levels can be regulated by various factors, including growth factors, cytokines, and mechanical forces.

Mutations or dysregulation of ITGB5 have been associated with several diseases, including cancer and cardiovascular disorders. For instance, the expression of integrin alpha-V beta-5 is often upregulated in cancer cells, contributing to tumor growth and metastasis. In cardiovascular diseases, the dysregulation of this integrin can lead to abnormal vascular remodeling and angiogenesis.

Research on ITGB5 continues to uncover its diverse functions and potential as a therapeutic target for various diseases. Understanding the molecular mechanisms underlying its regulation and function is essential for developing targeted therapies for conditions associated with its dysregulation.