IGF1like

IGF1like is a protein that belongs to the insulin-like growth factor (IGF) family, which plays a crucial role in various biological processes, including cell growth, differentiation, and survival. It is structurally similar to IGF1, sharing about 80% amino acid sequence identity, but it lacks the ability to bind to the IGF1 receptor. Instead, IGF1like interacts with the IGF2 receptor, which is also known as the mannose-6-phosphate receptor. This interaction is essential for the proper functioning of the lysosomal system, as IGF1like is involved in the trafficking and degradation of mannose-6-phosphate-containing proteins within lysosomes.

IGF1like is highly conserved across species, indicating its importance in fundamental biological processes. It is expressed in various tissues and cell types, with its expression levels often regulated by growth factors, hormones, and other signaling molecules. Dysregulation of IGF1like has been implicated in several diseases, including cancer, neurodegenerative disorders, and metabolic conditions. For instance, elevated levels of IGF1like have been observed in certain types of cancer, where it may contribute to tumor growth and progression. Additionally, mutations in the IGF1like gene have been associated with neurodegenerative diseases such as Alzheimer's and Parkinson's.

Research on IGF1like is ongoing, with scientists exploring its potential as a therapeutic target for various diseases. Understanding the molecular mechanisms underlying IGF1like function and regulation is crucial for developing effective strategies to modulate its activity and mitigate its detrimental effects in disease states.