mannose6phosphatecontaining

Mannose-6-phosphate-containing proteins are a class of enzymes and other proteins that contain mannose-6-phosphate (M6P) residues. These residues are typically attached to asparagine residues within the proteins. The presence of M6P is crucial for the proper functioning and targeting of these proteins within the cell.

Mannose-6-phosphate-containing proteins are involved in various cellular processes, including protein trafficking, endocytosis, and lysosomal degradation. The M6P residues are recognized by mannose-6-phosphate receptors (M6PRs) on the surface of endosomes and lysosomes. This recognition facilitates the binding and internalization of the proteins into these organelles, where they are either degraded or recycled.

The addition of M6P residues to proteins is catalyzed by the enzyme mannose-6-phosphate isomerase (MPI). This enzyme converts mannose-6-phosphate into fructose-6-phosphate, which is then used for the synthesis of other sugars. The removal of M6P residues from proteins is mediated by the enzyme mannose-6-phosphate phosphatase (MPP). This enzyme hydrolyzes the M6P residues, allowing the proteins to be recycled or exported from the cell.

Mannose-6-phosphate-containing proteins are found in a wide range of organisms, from bacteria to humans. They play essential roles in various biological processes, including metabolism, signaling, and immune response. The study of these proteins has provided valuable insights into the mechanisms of protein trafficking and the regulation of cellular processes.