HyperpolarisaatioDNPtä

HyperpolarisaatioDNPtä refers to a technique used to greatly enhance the sensitivity of Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI) experiments. DNP, or Dynamic Nuclear Polarization, is a method that transfers polarization from unpaired electrons in a paramagnetic dopant to nearby atomic nuclei. This transfer results in a significant increase in the nuclear spin polarization, often by factors of thousands or even hundreds of thousands.

The enhanced polarization leads to a dramatic improvement in the signal-to-noise ratio of NMR and MRI spectra. This allows for the detection of very low concentrations of substances or for the acquisition of images with unprecedented detail and speed. The technique typically involves irradiating a sample containing a paramagnetic substance and the analyte of interest with microwaves at cryogenic temperatures. The microwaves excite the electron spins, and through spin diffusion and cross-polarization mechanisms, this polarization is transferred to the target nuclei.

HyperpolarisaatioDNPtä has found applications in various fields, including chemistry, biology, and medicine. In chemistry, it enables the study of reaction mechanisms and the detection of short-lived intermediates. In biology, it allows for the non-invasive imaging of metabolic processes in vivo, providing insights into disease states such as cancer. The ability to achieve such high sensitivity opens up new possibilities for molecular imaging and diagnostics.