Homeostaasin

Homeostaasin is a hypothetical regulatory concept in biology describing a multi-layer system that maintains internal stability across scales. It is envisioned as an integration point for diverse sensory inputs—neural, hormonal, metabolic—and a coordinating mechanism that sets and stabilizes physiological set points through effector pathways.

Term origin and usage: The name blends “homeostasis” with a suffix reminiscent of signaling proteins; in speculative contexts it may denote either a molecular regulator, a signaling network, or an architectural principle that ensures coherent responses to perturbations.

In the proposed framework, homeostaasin functions as either a single regulatory molecule or a distributed network that receives inputs from sensors, compares current values to a target set point, and broadcasts corrective signals to effectors such as glands, muscles, and cellular pathways. It would operate via feedback loops, feedforward anticipation, and cross-organ communication to dampen fluctuations in variables like temperature, pH, glucose, and osmolarity.

Researchers sometimes distinguish a molecular homeostaasin (a protein or RNA with regulatory capability) from a network homeostaasin (a systems-level property of an interacting set of regulators).

While no empirical consensus exists, the concept is used in theoretical biology, systems biology, and science fiction to discuss how organisms could coordinate multiple regulatory axes or to inspire synthetic biology designs that mimic robust stability.

Related concepts include homeostasis, feedback control, sensory receptors, and endocrine regulation.