HipSTR
HipSTR is a software tool designed for accurate and efficient detection of genetic variants, specifically single nucleotide polymorphisms (SNPs) and short insertions and deletions (indels), in next-generation sequencing data. It is particularly well-suited for analyzing low-frequency variants, which are often challenging to identify reliably due to sequencing errors. HipSTR stands for "High-fidelity Insertion/Deletion STR" and emphasizes its capability in accurately calling both SNPs and indels, especially in repetitive regions where traditional methods may struggle.
The tool employs a statistical model that considers the read depth, base quality scores, and mapping quality