H2Bub1
H2Bub1 refers to the protein histone H2B that has been modified by the addition of a single ubiquitin molecule. This specific type of post-translational modification, known as ubiquitination, plays a crucial role in regulating gene expression and other cellular processes. Ubiquitin is a small protein that can be covalently attached to other proteins, altering their function, stability, or localization.
The ubiquitination of histone H2B at specific lysine residues, particularly lysine 120 in humans (K120), is
H2Bub1 is closely associated with actively transcribed genes. It is thought to facilitate the elongation phase