Geranylgeranylpyrophosphat
Geranylgeranylpyrophosphat, commonly known as geranylgeranyl pyrophosphate (GGPP), is a C20 isoprenoid diphosphate that functions as a donor of the geranylgeranyl group in protein prenylation. It is an intermediate in the mevalonate pathway, synthesized from farnesyl pyrophosphate (FPP) through the action of geranylgeranyl pyrophosphate synthase, with isopentenyl pyrophosphate (IPP) providing the additional five-carbon unit.
GGPP serves as the substrate for protein geranylgeranylation, a post-translational modification that anchors certain proteins to
Physiological and pharmacological relevance: The availability of GGPP influences prenylation status and protein function. Disruptions in
See also: mevalonate pathway, protein prenylation, farnesyl pyrophosphate, isoprenoid biosynthesis.