GRADEpro

GRADEpro, also known as GRADEpro GDT (Guideline Development Tool), is a software application designed to support the development of clinical guidelines and health technology assessments using the GRADE approach. It provides a structured platform for documenting judgments about the certainty of evidence and the strength of recommendations, helping guideline panels translate evidence into actionable statements.

Its core features include the creation of GRADE Evidence Profiles and Summary of Findings (SoF) tables, which summarize study results, effect estimates, and the certainty ratings for each outcome. The tool guides users through the domains of GRADE (risk of bias, imprecision, inconsistency, indirectness, and publication bias) to assign overall certainty. It also supports drafting recommendation statements with explicit strength and direction, along with rationale and links to the supporting evidence. Other capabilities often include data import from systematic reviews, study-level data organization, collaboration tools for multiple contributors, version control, and options to export content to common formats such as Word, PDF, or web-ready outputs.

GRADEpro is used by guideline developers, researchers, and health technology assessment teams to standardize the guideline development process and enhance transparency. It is compatible with the broader GRADE Working Group methodologies and is frequently employed in academic, governmental, and professional settings to produce clear, evidence-based recommendations.

Availability and updates: The software is distributed as a commercial product with different licensing options and ongoing development. Users typically access online and/or desktop versions, with documentation and support provided by the developers.